David Wraith

Join this session for a candid conversation around the future of T-cell depletion for immune reset:

• Debating the technical feasibility and current limitations of logic-gated CAR-T cells in autoimmunity
• Discussing the emerging paradigm of T-cell modulation vs elimination including the modalities most promising for safely silencing autoreactive T-cells without long-term safety risks
• Effectively measuring the resulting state of functional tolerance
• Exploring the combination of translational biomarkers and clinical trial endpoints necessary to validate the safety and disease specificity of targeted T-cell therapies