Pre-Conference Day

Defining Immune Resetting: Translational Approaches to Profiling B-Cells to Understand the Depth of Depletion

Join this workshop to discuss how we measure the immune reset and to what depth must we deplete B-Cells:

• Clarifying the constitution of a true ‘immune reset’ following B-cell depletion therapy vs transient immunosuppression
• Discussing the restoration of the stable self-tolerant immune system
• Understanding optimal depletion targets to understand which populations must be depleted and to what extent to achieve a sustainable therapeutic effect
• Reflecting on the necessary therapeutic strategies needed to target long-lived plasma cells within the bone marrow
• Advancing B-cell profiling techniques such as single-cell RNA sequencing, flow, and mass cytometry, and adaptive immune receptor repertoire sequencing
• Discussing the effective definition of B-cell depletion through cellular and molecular biomarkers that correlate with depletion depth and sustained immune reset

Advancing Clinical Biomarkers for Immune Reset to Definitively Characterize the B-Cell Repertoire & Success of Cell Therapies & T-Cell Engagers

Join this workshop to explore how immune resetting is being measured in the clinic:

• Assessment of B-cell reset in peripheral blood and tissue biopsies across autoimmune diseases
• Comparison of B-cell dynamics in lupus, rheumatoid arthritis, and Sjögren’s disease, including B-cell phenotyping and the impact of prior therapies
• CD19 T-cell engager development: expectations for detecting immune reset during dose escalation and the potential implications for Phase 2 dose and schedule selection
• B cell depletion and reconstitution following dual CD19/BCMA CART targeting in SLE/LN
• Phenotypes of B cells pre-treatment and post-reconstitution
• Potential comparison to other B cell targeting therapies