Defining Immune Resetting: Translational Approaches to Profiling B-Cells to Understand the Depth of Depletion

Join this workshop to discuss how we measure the immune reset and to what depth must we deplete B-Cells:

• Clarifying the constitution of a true ‘immune reset’ following B-cell depletion therapy vs transient immunosuppression
• Discussing the restoration of the stable self-tolerant immune system
• Understanding optimal depletion targets to understand which populations must be depleted and to what extent to achieve a sustainable therapeutic effect
• Reflecting on the necessary therapeutic strategies needed to target long-lived plasma cells within the bone marrow
• Advancing B-cell profiling techniques such as single-cell RNA sequencing, flow, and mass cytometry, and adaptive immune receptor repertoire sequencing
• Discussing the effective definition of B-cell depletion through cellular and molecular biomarkers that correlate with depletion depth and sustained immune reset