HB2198 GEM-DIMER™: A Novel Myeloid & NK Cell Engager for Deep Depletion of B-Cells
- HB2198 is an anti-CD19/CD20 bispecific antibody with dual enhanced Fc domains created with Hinge Bio’s GEM-DIMER™ technology
- HB2198 exhibits potent B-cell depletion in vitro, demonstrating ADCC, ADCP, CDC and direct killing
- HB2198 rapidly depletes B-cells and results in durable remodeling of the B-cell compartment in cynomolgus monkeys with no cytokine release up to 25 mg/kg. Preparations for Phase 1 clinical trial in SLE/LN ongoing